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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | L | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Smith Smith | 177 | 2002-2017 | |
| 2 | Bartolo Colon | 155 | 1997-2019 | |
| 2 | Aaron Harang | 155 | 2002-2015 | |
| 4 | Adam Wainwright | 154 | 2004-2023 | |
| 5 | CC Sabathia | 151 | 2002-2020 | |
| 6 | J.J. Franco | 146 | 1999-2014 | |
| 7 | Smith Smith | 145 | 2006-2020 | |
| 8 | Catfish Hunter | 142 | 1965-1976 | |
| 9 | Felix Hernandez | 141 | 2005-2021 | |
| 9 | John Lackey | 141 | 2003-2017 | |
| 11 | Clayton Kershaw# | 136 | 2009-2025 | |
| 12 | Charlie Morton# | 135 | 2010-2025 | |
| 13 | Patrick Corbin# | 134 | 2012-2026 | |
| 14 | Lance Lynn# | 130 | 2010-2025 | |
| 14 | Jordan Zimmermann | 130 | 2010-2021 | |
| 16 | Jake Arrieta | 128 | 2011-2022 | |
| 16 | Cole Hamels | 128 | 2007-2022 | |
| 16 | Brandon McCarthy | 128 | 2006-2019 | |
| 19 | Scott Kazmir | 127 | 2005-2018 | |
| 20 | Jon Lester | 126 | 2007-2021 | |
| 21 | Jake Peavy | 125 | 2002-2018 | |
| 22 | Kevin Gausman# | 124 | 2013-2026 | |
| 23 | Michael Pineda | 123 | 2011-2023 | |
| 23 | Zack Wheeler# | 123 | 2010-2026 | |
| 25 | Alex Cobb# | 122 | 2012-2025 | |
| 25 | Rich Hill# | 122 | 2006-2023 | |
| 27 | Johnny Cueto | 121 | 2010-2023 | |
| 27 | Max Scherzer# | 121 | 2009-2026 | |
| 29 | John Danks | 118 | 2008-2018 | |
| 29 | Gavin Floyd | 118 | 2005-2017 | |
| 31 | Larry Dierker | 117 | 1964-1976 | |
| 31 | Justin Verlander# | 117 | 2007-2026 | |
| 33 | James Shields | 116 | 2007-2019 | |
| 34 | Anibal Sanchez | 115 | 2007-2021 | |
| 35 | Stephen Strasburg | 114 | 2010-2025 | |
| 36 | Brett Anderson | 112 | 2010-2021 | |
| 36 | Jose Quintana# | 112 | 2013-2025 | |
| 38 | Johnny Antonelli | 110 | 1948-1961 | |
| 38 | Michael Wacha# | 110 | 2015-2026 | |
| 40 | Danny Duffy | 109 | 2012-2022 | |
| 41 | Jon Gray# | 108 | 2015-2026 | |
| 42 | Brett Myers | 107 | 2003-2014 | |
| 43 | Jameson Taillon# | 105 | 2014-2026 | |
| 43 | Edinson Volquez | 105 | 2008-2020 | |
| 45 | Madison Bumgarner | 104 | 2011-2023 | |
| 45 | Julio Teheran | 104 | 2011-2022 | |
| 47 | Clay Buchholz | 103 | 2008-2020 | |
| 47 | Dylan Bundy | 103 | 2012-2023 | |
| 47 | Gio Gonzalez | 103 | 2010-2022 | |
| 47 | Jered Weaver | 103 | 2007-2017 | |
| 51 | Matt Cain | 102 | 2006-2019 | |
| 51 | Chris Sale# | 102 | 2011-2026 | |
| 53 | Sonny Gray# | 101 | 2012-2026 | |
| 54 | Billy O'Dell | 100 | 1954-1967 | |
| 55 | Homer Bailey | 99 | 2009-2020 | |
| 55 | James Happ | 99 | 2009-2022 | |
| 55 | Kyle Hendricks# | 99 | 2016-2024 | |
| 55 | Matt Moore# | 99 | 2012-2025 | |
| 55 | Chris Young | 99 | 2004-2016 | |
| 60 | Gerrit Cole# | 98 | 2012-2026 | |
| 60 | Ervin Santana | 98 | 2002-2019 | |
| 62 | Smith Smith | 97 | 2004-2017 | |
| 63 | Josh M. Johnson | 95 | 2006-2017 | |
| 63 | Rick Porcello | 95 | 2011-2021 | |
| 65 | Garrett Richards | 92 | 2012-2022 | |
| 65 | Smith Smith | 92 | 2003-2017 | |
| 65 | Taijuan Walker# | 92 | 2012-2026 | |
| 68 | Nathan Eovaldi# | 91 | 2012-2026 | |
| 68 | Ryan Madson | 91 | 2003-2019 | |
| 68 | Mike Minor | 91 | 2010-2023 | |
| 71 | Carlos Carrasco | 90 | 2010-2023 | |
| 71 | Bob Feller | 90 | 1947-1956 | |
| 71 | Tyler Mahle# | 90 | 2017-2026 | |
| 71 | Paul Maholm | 90 | 2006-2015 | |
| 71 | Miles Mikolas# | 90 | 2010-2025 | |
| 71 | Ricky Nolasco | 90 | 2007-2017 | |
| 77 | Joe Blanton | 88 | 2006-2017 | |
| 77 | Wade Miley# | 88 | 2010-2024 | |
| 77 | Jordan Montgomery# | 88 | 2015-2026 | |
| 77 | Masahiro Tanaka | 88 | 2014-2021 | |
| 81 | Sandy Koufax | 87 | 1955-1966 | |
| 82 | Mike Pelfrey | 86 | 2008-2017 | |
| 82 | Hyun-Jin Ryu | 86 | 2013-2023 | |
| 84 | Yu Darvish# | 85 | 2012-2026 | |
| 84 | Jason Hammel | 85 | 2008-2018 | |
| 86 | Chris Bassitt# | 84 | 2016-2026 | |
| 86 | Phil Hughes | 84 | 2009-2018 | |
| 86 | Smith Smith | 84 | 2008-2017 | |
| 86 | Josh Tomlin | 84 | 2011-2022 | |
| 90 | Jeff Samardzija | 83 | 2010-2020 | |
| 91 | Tyler Anderson# | 82 | 2012-2026 | |
| 91 | Kyle Gibson# | 82 | 2010-2025 | |
| 91 | German Marquez# | 82 | 2018-2025 | |
| 94 | Matt Garza | 81 | 2009-2017 | |
| 94 | Mike Leake | 81 | 2010-2020 | |
| 94 | Tyson Ross | 81 | 2012-2019 | |
| 97 | Wade Davis | 80 | 2009-2020 | |
| 97 | Kenta Maeda# | 80 | 2016-2025 | |
| 97 | James Paxton# | 80 | 2014-2025 | |
| 97 | Martin Perez# | 80 | 2010-2025 |
