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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | WPCT | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Pablo Lopez# | .681 | 2021-2025 | |
| 2 | Trevor Bauer | .670 | 2012-2023 | |
| 3 | Corbin Burnes# | .667 | 2020-2025 | |
| 4 | Shohei Ohtani# | .656 | 2018-2025 | |
| 5 | Sandy Koufax | .655 | 1955-1966 | |
| 6 | David Price | .651 | 2009-2023 | |
| 7 | Matt Belisle | .647 | 2004-2018 | |
| 8 | Justin Verlander# | .635 | 2007-2025 | |
| 9 | Jeff Locke | .633 | 2011-2017 | |
| 10 | Tarik Skubal# | .632 | 2022-2025 | |
| 11 | Jacob Degrom# | .629 | 2012-2025 | |
| 12 | Josh M. Johnson | .627 | 2006-2017 | |
| 13 | Yu Darvish# | .614 | 2012-2025 | |
| 14 | Lance McCullers Jr.# | .613 | 2016-2025 | |
| 15 | Walker Buehler# | .612 | 2019-2025 | |
| 16 | Chad Billingsley | .608 | 2007-2015 | |
| 17 | CC Sabathia | .607 | 2002-2020 | |
| 18 | Neftali Feliz | .606 | 2010-2018 | |
| 19 | Mat Latos | .603 | 2010-2016 | |
| 20 | Jose De Leon# | .600 | 2017-2022 | |
| 20 | Zac Gallen# | .600 | 2020-2025 | |
| 22 | Lucas Giolito# | .599 | 2016-2025 | |
| 22 | Max Scherzer# | .599 | 2009-2025 | |
| 24 | Dylan Cease# | .595 | 2015-2025 | |
| 25 | Max Fried# | .594 | 2018-2025 | |
| 26 | Collin McHugh | .593 | 2010-2024 | |
| 26 | Ubaldo Jimenez | .593 | 2010-2020 | |
| 28 | Michael Lorenzen# | .592 | 2018-2025 | |
| 28 | Aaron Nola# | .592 | 2015-2025 | |
| 30 | Logan Webb# | .589 | 2015-2025 | |
| 31 | Freddy Peralta# | .587 | 2019-2025 | |
| 31 | Bob Feller | .587 | 1947-1956 | |
| 33 | Catfish Hunter | .586 | 1965-1976 | |
| 34 | Robbie Ray# | .585 | 2017-2025 | |
| 35 | Jake Peavy | .583 | 2002-2018 | |
| 36 | Andrew Miller | .582 | 2007-2020 | |
| 36 | Brad Ziegler | .582 | 2007-2018 | |
| 38 | Jerry Blevins | .581 | 2008-2018 | |
| 39 | Yusei Kikuchi# | .580 | 2019-2025 | |
| 40 | Nathan Eovaldi# | .579 | 2012-2025 | |
| 41 | Marcus Stroman# | .574 | 2015-2025 | |
| 41 | Bryse Wilson# | .574 | 2020-2025 | |
| 43 | Steve Matz# | .572 | 2010-2025 | |
| 43 | Clayton Kershaw# | .572 | 2009-2025 | |
| 45 | Gerrit Cole# | .571 | 2012-2025 | |
| 45 | Danny Salazar | .571 | 2010-2021 | |
| 47 | Jake Odorizzi | .570 | 2012-2023 | |
| 47 | Shane Bieber# | .570 | 2020-2025 | |
| 47 | Tom Gorzelanny | .570 | 2007-2016 | |
| 50 | Framber Valdez# | .567 | 2022-2025 | |
| 51 | Nick Pivetta# | .566 | 2019-2025 | |
| 51 | Carlos Rodon# | .566 | 2015-2025 | |
| 51 | Matt Andriese | .566 | 2012-2023 | |
| 51 | Ian Kennedy | .566 | 2010-2022 | |
| 51 | Wily Peralta | .566 | 2012-2019 | |
| 56 | Tyler Glasnow# | .565 | 2017-2025 | |
| 57 | Matt Strahm# | .564 | 2016-2025 | |
| 58 | Steve Hamilton | .563 | 1961-1972 | |
| 59 | Tim Lincecum | .562 | 2009-2018 | |
| 59 | Stephen Strasburg | .562 | 2010-2025 | |
| 61 | Kyle Gibson# | .561 | 2010-2025 | |
| 61 | Jesse Chavez# | .561 | 2010-2025 | |
| 61 | Luis Severino# | .561 | 2016-2025 | |
| 64 | Scott Baker | .559 | 2006-2014 | |
| 65 | Santiago Casilla | .557 | 2005-2017 | |
| 66 | Joe Musgrove# | .556 | 2012-2025 | |
| 66 | Oliver Perez | .556 | 2003-2022 | |
| 66 | Jarrod Parker | .556 | 2012-2015 | |
| 69 | Joe Nathan | .553 | 2000-2016 | |
| 69 | Joe Smith | .553 | 2008-2022 | |
| 71 | Andrew Cashner | .551 | 2011-2020 | |
| 71 | Smith Smith | .551 | 2004-2017 | |
| 73 | Matthew Boyd# | .550 | 2019-2025 | |
| 74 | Darren O'Day | .548 | 2010-2022 | |
| 75 | Johnny Cueto | .547 | 2010-2023 | |
| 75 | Matt Cain | .547 | 2006-2019 | |
| 77 | Jose Berrios# | .546 | 2016-2025 | |
| 78 | Brandon Woodruff# | .545 | 2015-2025 | |
| 79 | German Marquez# | .544 | 2018-2025 | |
| 80 | Ricky Nolasco | .543 | 2007-2017 | |
| 80 | Adam Wainwright | .543 | 2004-2023 | |
| 80 | Corey Kluber | .543 | 2011-2023 | |
| 83 | Felix Hernandez | .542 | 2005-2021 | |
| 83 | Jon Lester | .542 | 2007-2021 | |
| 83 | Chris Sale# | .542 | 2011-2025 | |
| 86 | Rich Harden | .541 | 2004-2013 | |
| 86 | Zack Wheeler# | .541 | 2010-2025 | |
| 88 | Justin Masterson | .540 | 2010-2016 | |
| 89 | Larry Dierker | .539 | 1964-1976 | |
| 89 | David Robertson# | .539 | 2010-2025 | |
| 91 | Cole Hamels | .538 | 2007-2022 | |
| 92 | Zach Eflin# | .537 | 2018-2025 | |
| 92 | Liam Hendriks# | .537 | 2012-2025 | |
| 94 | Andrew Heaney# | .536 | 2018-2025 | |
| 95 | Matt Harvey | .535 | 2014-2021 | |
| 96 | Johnny Antonelli | .534 | 1948-1961 | |
| 97 | Chris Paddack# | .532 | 2020-2025 | |
| 98 | Neal Cotts | .531 | 2005-2016 | |
| 98 | Jeff Samardzija | .531 | 2010-2020 | |
| 98 | Blake Snell# | .531 | 2012-2025 |
