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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Clayton Kershaw# | 3055 | 2009-2025 | |
| 2 | Max Scherzer# | 2960 | 2009-2025 | |
| 3 | Justin Verlander# | 2860 | 2007-2025 | |
| 4 | CC Sabathia | 2824 | 2002-2020 | |
| 5 | Felix Hernandez | 2786 | 2005-2021 | |
| 6 | Smith Smith | 2617 | 2006-2020 | |
| 7 | Jake Peavy | 2578 | 2002-2018 | |
| 8 | Cole Hamels | 2566 | 2007-2022 | |
| 9 | Stephen Strasburg | 2433 | 2010-2025 | |
| 10 | Sandy Koufax | 2396 | 1955-1966 | |
| 11 | Adam Wainwright | 2357 | 2004-2023 | |
| 12 | Lance Lynn# | 2266 | 2010-2025 | |
| 13 | Jon Lester | 2260 | 2007-2021 | |
| 14 | Scott Kazmir | 2213 | 2005-2018 | |
| 15 | Yu Darvish# | 2157 | 2012-2025 | |
| 16 | John Lackey | 2154 | 2003-2017 | |
| 17 | Gerrit Cole# | 2107 | 2012-2025 | |
| 18 | Zack Wheeler# | 2102 | 2010-2025 | |
| 19 | Josh M. Johnson | 2099 | 2006-2017 | |
| 20 | Chris Sale# | 2089 | 2011-2025 | |
| 21 | David Price | 2063 | 2009-2023 | |
| 22 | Bartolo Colon | 2060 | 1997-2019 | |
| 23 | Smith Smith | 2054 | 2004-2017 | |
| 24 | Johnny Cueto | 2011 | 2010-2023 | |
| 25 | J.J. Franco | 1998 | 1999-2014 | |
| 26 | Charlie Morton# | 1979 | 2010-2025 | |
| 27 | Anibal Sanchez | 1973 | 2007-2021 | |
| 28 | Catfish Hunter | 1870 | 1965-1976 | |
| 29 | Kevin Gausman# | 1858 | 2013-2025 | |
| 30 | Michael Pineda | 1848 | 2011-2023 | |
| 31 | Matt Cain | 1847 | 2006-2019 | |
| 32 | Aaron Harang | 1811 | 2002-2015 | |
| 33 | Jacob Degrom# | 1799 | 2012-2025 | |
| 34 | James Shields | 1798 | 2007-2019 | |
| 35 | Edinson Volquez | 1784 | 2008-2020 | |
| 36 | Rich Hill# | 1778 | 2006-2023 | |
| 37 | Gio Gonzalez | 1766 | 2010-2022 | |
| 38 | Jered Weaver | 1738 | 2007-2017 | |
| 39 | Smith Smith | 1732 | 2002-2017 | |
| 40 | Patrick Corbin# | 1729 | 2012-2024 | |
| 41 | Lance McCullers Jr.# | 1722 | 2016-2025 | |
| 42 | Jake Arrieta | 1695 | 2011-2022 | |
| 43 | Brett Myers | 1675 | 2003-2014 | |
| 44 | James Happ | 1613 | 2009-2022 | |
| 45 | Tim Lincecum | 1611 | 2009-2018 | |
| 46 | Jon Gray# | 1608 | 2015-2025 | |
| 47 | Jose Quintana# | 1606 | 2013-2025 | |
| 48 | Nathan Eovaldi# | 1595 | 2012-2025 | |
| 49 | Madison Bumgarner | 1585 | 2011-2023 | |
| 50 | Matt Moore# | 1577 | 2012-2025 | |
| 51 | Clay Buchholz | 1570 | 2008-2020 | |
| 52 | Jordan Zimmermann | 1567 | 2010-2021 | |
| 53 | Ian Kennedy | 1566 | 2010-2022 | |
| 54 | Chris Archer | 1562 | 2012-2023 | |
| 55 | Alex Cobb# | 1555 | 2012-2025 | |
| 56 | Brandon McCarthy | 1537 | 2006-2019 | |
| 57 | Julio Teheran | 1532 | 2011-2022 | |
| 58 | Jameson Taillon# | 1520 | 2014-2025 | |
| 58 | Chris Young | 1520 | 2004-2016 | |
| 60 | Ricky Nolasco | 1500 | 2007-2017 | |
| 61 | Sonny Gray# | 1488 | 2012-2025 | |
| 62 | Larry Dierker | 1487 | 1964-1976 | |
| 63 | Lucas Giolito# | 1481 | 2016-2025 | |
| 64 | Oliver Perez | 1474 | 2003-2022 | |
| 64 | Jeff Samardzija | 1474 | 2010-2020 | |
| 66 | James Paxton# | 1466 | 2014-2025 | |
| 67 | Michael Wacha# | 1451 | 2015-2025 | |
| 68 | Tyler Mahle# | 1435 | 2017-2025 | |
| 69 | Phil Hughes | 1434 | 2009-2018 | |
| 70 | Chad Billingsley | 1426 | 2007-2015 | |
| 71 | Brett Anderson | 1423 | 2010-2021 | |
| 72 | Aroldis Chapman# | 1413 | 2011-2025 | |
| 73 | Masahiro Tanaka | 1412 | 2014-2021 | |
| 74 | Ervin Santana | 1402 | 2002-2019 | |
| 75 | John Danks | 1399 | 2008-2018 | |
| 75 | Brandon Woodruff# | 1399 | 2015-2025 | |
| 77 | Brandon Morrow | 1396 | 2009-2020 | |
| 78 | Mike Minor | 1395 | 2010-2023 | |
| 78 | Danny Salazar | 1395 | 2010-2021 | |
| 78 | Blake Snell# | 1395 | 2012-2025 | |
| 81 | Luis Severino# | 1385 | 2016-2025 | |
| 82 | Rich Harden | 1383 | 2004-2013 | |
| 83 | Aaron Nola# | 1370 | 2015-2025 | |
| 84 | Matt Garza | 1354 | 2009-2017 | |
| 85 | Tyler Glasnow# | 1351 | 2017-2025 | |
| 86 | Carlos Carrasco | 1342 | 2010-2023 | |
| 87 | Craig Kimbrel# | 1341 | 2011-2025 | |
| 88 | Robbie Ray# | 1320 | 2017-2025 | |
| 88 | Carlos Rodon# | 1320 | 2015-2025 | |
| 90 | Smith Smith | 1307 | 2008-2017 | |
| 91 | Ubaldo Jimenez | 1306 | 2010-2020 | |
| 92 | Hyun-Jin Ryu | 1303 | 2013-2023 | |
| 93 | Rick Porcello | 1294 | 2011-2021 | |
| 94 | Dylan Bundy | 1290 | 2012-2023 | |
| 95 | Matt Harvey | 1284 | 2014-2021 | |
| 95 | Corey Kluber | 1284 | 2011-2023 | |
| 97 | Kenta Maeda# | 1260 | 2016-2025 | |
| 97 | German Marquez# | 1260 | 2018-2025 | |
| 97 | Collin McHugh | 1260 | 2010-2024 | |
| 100 | Freddy Peralta# | 1258 | 2019-2025 |
