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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Clayton Kershaw# | 42.0 | 2015 | |
| 2 | Max Scherzer# | 39.0 | 2013 | |
| 3 | Madison Bumgarner | 36.0 | 2018 | |
| 4 | Gio Gonzalez | 35.0 | 2014 | |
| 4 | Jacob Degrom# | 35.0 | 2024 | |
| 6 | Yu Darvish# | 34.0 | 2013 | |
| 7 | Shane McClanahan# | 33.0 | 2025 | |
| 7 | Stephen Strasburg | 33.0 | 2015 | |
| 9 | Aaron Nola# | 32.0 | 2019 | |
| 9 | Corbin Burnes# | 32.0 | 2025 | |
| 9 | Corbin Burnes# | 32.0 | 2024 | |
| 9 | Max Scherzer# | 32.0 | 2018 | |
| 9 | Madison Bumgarner | 32.0 | 2017 | |
| 9 | Justin Souza | 32.0 | 2012 | |
| 15 | David Price | 31.0 | 2016 | |
| 15 | Catfish Hunter | 31.0 | 1972 | |
| 17 | Corey Kluber | 30.0 | 2016 | |
| 17 | Jon Niese | 30.0 | 2014 | |
| 17 | David Price | 30.0 | 2015 | |
| 17 | Edinson Volquez | 30.0 | 2014 | |
| 17 | Homer Bailey | 30.0 | 2016 | |
| 17 | Pablo Lopez# | 30.0 | 2024 | |
| 17 | Chris Jones | 30.0 | 2012 | |
| 24 | Mat Latos | 29.0 | 2015 | |
| 24 | Catfish Hunter | 29.0 | 1973 | |
| 24 | Christian Friedrich | 29.0 | 2011 | |
| 24 | Zac Gallen# | 29.0 | 2025 | |
| 28 | Adam Wainwright | 28.0 | 2017 | |
| 28 | Kyle Hendricks# | 28.0 | 2022 | |
| 28 | Wade Davis | 28.0 | 2013 | |
| 28 | Carlos Carrasco | 28.0 | 2021 | |
| 28 | Jose Junior Rosario | 28.0 | 2012 | |
| 28 | Jose Quintana# | 28.0 | 2018 | |
| 28 | Gerrit Cole# | 28.0 | 2018 | |
| 35 | Julio Urias# | 27.0 | 2025 | |
| 35 | Miguel Celestino | 27.0 | 2012 | |
| 35 | Kevin Gausman# | 27.0 | 2022 | |
| 35 | Blake Snell# | 27.0 | 2022 | |
| 35 | Jacob Degrom# | 27.0 | 2025 | |
| 35 | Gerrit Cole# | 27.0 | 2017 | |
| 41 | Patrick Sandoval# | 26.0 | 2022 | |
| 41 | Justin Verlander# | 26.0 | 2015 | |
| 41 | Aaron Nola# | 26.0 | 2017 | |
| 44 | Clayton Kershaw# | 25.0 | 2021 | |
| 44 | Ross Detwiler | 25.0 | 2013 | |
| 44 | German Marquez# | 25.0 | 2022 | |
| 44 | Matt Manning# | 25.0 | 2022 | |
| 48 | Hyun-Jin Ryu | 24.0 | 2020 | |
| 48 | David Price | 24.0 | 2017 | |
| 48 | Carlos Carrasco | 24.0 | 2019 | |
| 48 | Erik Davis | 24.0 | 2012 | |
| 48 | Sandy Koufax | 24.0 | 1965 | |
| 48 | Jeurys Familia | 24.0 | 2011 | |
| 54 | John Danks | 23.0 | 2013 | |
| 54 | Patrick Corbin# | 23.0 | 2019 | |
| 54 | Miles Mikolas# | 23.0 | 2021 | |
| 54 | Corbin Burnes# | 23.0 | 2023 | |
| 54 | Marcus Stroman# | 23.0 | 2017 | |
| 54 | Carlos Rodon# | 23.0 | 2024 | |
| 60 | Matthew Boyd# | 22.0 | 2021 | |
| 60 | Shohei Ohtani# | 22.0 | 2023 | |
| 60 | Jeff Ames | 22.0 | 2012 | |
| 60 | Jeremy Hellickson | 22.0 | 2014 | |
| 60 | Marcus Stroman# | 22.0 | 2015 | |
| 60 | Spencer Schwellenbach# | 22.0 | 2025 | |
| 60 | Pablo Lopez# | 22.0 | 2025 | |
| 60 | Tyler Mahle# | 22.0 | 2021 | |
| 60 | Walker Buehler# | 22.0 | 2020 | |
| 69 | Carlos Frias | 21.0 | 2012 | |
| 69 | Spencer Strider# | 21.0 | 2025 | |
| 69 | Kodai Senga# | 21.0 | 2023 | |
| 69 | Maikel Cleto | 21.0 | 2012 | |
| 69 | Shohei Ohtani# | 21.0 | 2020 | |
| 69 | Aaron Nola# | 21.0 | 2021 | |
| 69 | Josh Smoker | 21.0 | 2012 | |
| 69 | Smith Smith | 21.0 | 2013 | |
| 69 | Nick Martinez# | 21.0 | 2024 | |
| 69 | Luis Patino# | 21.0 | 2022 | |
| 69 | Justin Verlander# | 21.0 | 2020 | |
| 69 | Jaime Garcia | 21.0 | 2014 | |
| 81 | Shane McClanahan# | 20.0 | 2023 | |
| 81 | Jeurys Familia | 20.0 | 2012 | |
| 81 | Catfish Hunter | 20.0 | 1976 | |
| 81 | Johnny Cueto | 20.0 | 2021 | |
| 81 | Chris Archer | 20.0 | 2019 | |
| 81 | Johnny Cueto | 20.0 | 2017 | |
| 81 | Zack Wheeler# | 20.0 | 2019 | |
| 81 | Cory Luebke | 20.0 | 2013 | |
| 81 | Collin McHugh | 20.0 | 2016 | |
| 81 | Lisalberto Bonilla | 20.0 | 2012 | |
| 81 | Lance McCullers Jr.# | 20.0 | 2017 | |
| 81 | Lance McCullers Jr.# | 20.0 | 2021 | |
| 81 | Shawn Armstrong# | 20.0 | 2012 | |
| 81 | Kendry Flores | 20.0 | 2019 | |
| 81 | German Marquez# | 20.0 | 2018 | |
| 96 | Justin Verlander# | 19.0 | 2014 | |
| 96 | Chad Bettis | 19.0 | 2012 | |
| 96 | Aaron Nola# | 19.0 | 2023 | |
| 96 | Jake Odorizzi | 19.0 | 2019 | |
| 96 | Vladimir Gutierrez# | 19.0 | 2022 |
