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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Edwin Jackson | 13.34 | 2004 | |
| 2 | Yu Darvish# | 13.21 | 2015 | |
| 3 | Spencer Strider# | 12.90 | 2025 | |
| 4 | J.J. Franco | 12.66 | 2004 | |
| 5 | Yu Darvish# | 12.63 | 2014 | |
| 5 | Lucas Giolito# | 12.63 | 2020 | |
| 7 | Spencer Strider# | 12.59 | 2024 | |
| 8 | Smith Smith | 12.38 | 2015 | |
| 9 | Jacob Degrom# | 12.23 | 2024 | |
| 10 | Jacob Degrom# | 12.06 | 2025 | |
| 10 | Yu Darvish# | 12.06 | 2013 | |
| 12 | Felix Hernandez | 12.05 | 2014 | |
| 13 | Justin Verlander# | 11.79 | 2020 | |
| 14 | Stephen Strasburg | 11.59 | 2013 | |
| 15 | Max Scherzer# | 11.56 | 2020 | |
| 15 | Matt Moore# | 11.56 | 2014 | |
| 17 | Oliver Perez | 11.50 | 2005 | |
| 18 | Rich Harden | 11.48 | 2010 | |
| 19 | Tyler Glasnow# | 11.45 | 2022 | |
| 20 | Jon Lester | 11.44 | 2015 | |
| 21 | Neftali Feliz | 11.43 | 2013 | |
| 22 | Stephen Strasburg | 11.42 | 2016 | |
| 23 | Rich Hill# | 11.40 | 2018 | |
| 24 | Tim Lincecum | 11.39 | 2011 | |
| 25 | Roki Sasaki# | 11.36 | 2025 | |
| 26 | Gerrit Cole# | 11.35 | 2020 | |
| 26 | Mike Clevinger# | 11.35 | 2020 | |
| 28 | Marco Estrada | 11.30 | 2014 | |
| 29 | Smith Smith | 11.28 | 2014 | |
| 30 | Luis Severino# | 11.25 | 2020 | |
| 31 | Gerrit Cole# | 11.22 | 2025 | |
| 32 | Tim Lincecum | 11.20 | 2010 | |
| 33 | Tyler Glasnow# | 11.16 | 2025 | |
| 34 | Stephen Strasburg | 11.15 | 2014 | |
| 35 | Matt Harvey | 11.13 | 2015 | |
| 36 | Marco Estrada | 11.12 | 2015 | |
| 37 | Clayton Kershaw# | 11.11 | 2015 | |
| 38 | Patrick Corbin# | 11.07 | 2018 | |
| 39 | Tim Lincecum | 11.04 | 2012 | |
| 40 | Brandon Morrow | 11.02 | 2013 | |
| 40 | Smith Smith | 11.02 | 2014 | |
| 42 | David Price | 11.01 | 2015 | |
| 43 | David Price | 10.97 | 2014 | |
| 44 | Mitch Keller# | 10.96 | 2020 | |
| 45 | Gerrit Cole# | 10.95 | 2021 | |
| 45 | Bartolo Colon | 10.95 | 2001 | |
| 47 | Blake Snell# | 10.87 | 2022 | |
| 48 | Justin Verlander# | 10.85 | 2015 | |
| 48 | Freddy Peralta# | 10.85 | 2022 | |
| 50 | Danny Salazar | 10.84 | 2018 | |
| 51 | Shane Bieber# | 10.81 | 2022 | |
| 52 | James Paxton# | 10.80 | 2019 | |
| 53 | Anibal Sanchez | 10.79 | 2015 | |
| 53 | Chris Archer | 10.79 | 2015 | |
| 55 | Felix Hernandez | 10.78 | 2015 | |
| 55 | Mat Latos | 10.78 | 2015 | |
| 57 | Jake Peavy | 10.77 | 2015 | |
| 58 | Chris Sale# | 10.76 | 2014 | |
| 59 | Felix Hernandez | 10.72 | 2016 | |
| 60 | Cole Hamels | 10.68 | 2014 | |
| 60 | Max Scherzer# | 10.68 | 2014 | |
| 62 | Chad Billingsley | 10.66 | 2013 | |
| 63 | Chris Sale# | 10.65 | 2016 | |
| 64 | Max Scherzer# | 10.63 | 2015 | |
| 64 | Ian Kennedy | 10.63 | 2014 | |
| 66 | Shohei Ohtani# | 10.62 | 2019 | |
| 66 | Reid Detmers# | 10.62 | 2025 | |
| 68 | Patrick Corbin# | 10.60 | 2019 | |
| 69 | Robbie Ross Jr. | 10.57 | 2010 | |
| 70 | Jeff Samardzija | 10.56 | 2014 | |
| 70 | Clayton Kershaw# | 10.56 | 2011 | |
| 72 | Sandy Koufax | 10.55 | 1962 | |
| 73 | Clayton Kershaw# | 10.54 | 2010 | |
| 73 | Walker Buehler# | 10.54 | 2019 | |
| 73 | Matt Garza | 10.54 | 2014 | |
| 76 | Jeff Samardzija | 10.52 | 2015 | |
| 76 | Jack Flaherty# | 10.52 | 2025 | |
| 78 | Clayton Kershaw# | 10.51 | 2013 | |
| 78 | Max Scherzer# | 10.51 | 2019 | |
| 80 | Jarrod Parker | 10.50 | 2013 | |
| 81 | Zack Wheeler# | 10.48 | 2015 | |
| 82 | John Danks | 10.46 | 2011 | |
| 82 | Matt Moore# | 10.46 | 2015 | |
| 82 | Jacob Degrom# | 10.46 | 2022 | |
| 82 | Tyler Mahle# | 10.46 | 2020 | |
| 86 | Matt Moore# | 10.45 | 2012 | |
| 86 | Edinson Volquez | 10.45 | 2011 | |
| 88 | Hunter Greene# | 10.42 | 2025 | |
| 89 | Anibal Sanchez | 10.41 | 2014 | |
| 90 | Clayton Kershaw# | 10.40 | 2014 | |
| 90 | Smith Smith | 10.40 | 2013 | |
| 92 | Smith Smith | 10.37 | 2008 | |
| 92 | Julio Urias# | 10.37 | 2020 | |
| 92 | Jon Lester | 10.37 | 2014 | |
| 95 | Wilmer Font | 10.36 | 2019 | |
| 96 | Tim Lincecum | 10.35 | 2013 | |
| 97 | Stephen Strasburg | 10.34 | 2012 | |
| 98 | Cole Hamels | 10.33 | 2013 | |
| 99 | CC Sabathia | 10.31 | 2013 | |
| 100 | Carlos Rodon# | 10.30 | 2025 |
