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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OOPS | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Sandy Koufax | .4598 | 1963 | |
| 2 | Sandy Koufax | .4636 | 1965 | |
| 3 | Sandy Koufax | .4692 | 1964 | |
| 4 | Catfish Hunter | .4761 | 1972 | |
| 5 | Sandy Koufax | .4918 | 1966 | |
| 6 | Larry Dierker | .5074 | 1969 | |
| 7 | Sandy Koufax | .5088 | 1962 | |
| 8 | Catfish Hunter | .5148 | 1975 | |
| 9 | Tarik Skubal# | .5251 | 2026 | |
| 10 | Catfish Hunter | .5283 | 1974 | |
| 11 | Catfish Hunter | .5330 | 1967 | |
| 12 | Bob Feller | .5343 | 1947 | |
| 13 | Shane Bieber# | .5394 | 2022 | |
| 14 | Yu Darvish# | .5450 | 2015 | |
| 15 | Patrick Corbin# | .5473 | 2018 | |
| 16 | Anthony Bass | .5495 | 2011 | |
| 17 | Billy O'Dell | .5539 | 1958 | |
| 18 | Bill Stafford | .5568 | 1961 | |
| 19 | Max Scherzer# | .5569 | 2020 | |
| 20 | Johnny Antonelli | .5610 | 1954 | |
| 21 | Billy O'Dell | .5618 | 1959 | |
| 22 | Felix Hernandez | .5619 | 2012 | |
| 23 | Johnny Antonelli | .5640 | 1956 | |
| 23 | Wade Miley# | .5640 | 2010 | |
| 25 | Catfish Hunter | .5641 | 1971 | |
| 25 | Yu Darvish# | .5641 | 2014 | |
| 27 | John Lackey | .5657 | 2008 | |
| 28 | Freddy Peralta# | .5658 | 2024 | |
| 29 | Tim Melville | .5666 | 2011 | |
| 30 | Robbie Ross Jr. | .5668 | 2010 | |
| 31 | Charlie Shirek | .5684 | 2011 | |
| 31 | Lucas Giolito# | .5684 | 2020 | |
| 33 | Stephen Strasburg | .5716 | 2014 | |
| 34 | Larry Dierker | .5726 | 1974 | |
| 35 | Felix Hernandez | .5732 | 2013 | |
| 36 | Larry Dierker | .5734 | 1968 | |
| 37 | Larry Dierker | .5742 | 1976 | |
| 38 | Catfish Hunter | .5747 | 1976 | |
| 39 | Smith Smith | .5758 | 2013 | |
| 40 | Bartolo Colon | .5785 | 2001 | |
| 41 | David Price | .5791 | 2015 | |
| 42 | Johnny Antonelli | .5819 | 1959 | |
| 43 | Kyle McPherson | .5832 | 2011 | |
| 44 | Larry Dierker | .5839 | 1972 | |
| 45 | Larry Dierker | .5842 | 1966 | |
| 46 | Cole Ragans# | .5851 | 2026 | |
| 47 | Sandy Koufax | .5857 | 1961 | |
| 48 | Yu Darvish# | .5882 | 2013 | |
| 49 | Clayton Kershaw# | .5897 | 2015 | |
| 50 | Greg Smith | .5898 | 2010 | |
| 51 | Lucas Giolito# | .5907 | 2021 | |
| 52 | Zack Wheeler# | .5920 | 2022 | |
| 53 | Felix Hernandez | .5921 | 2015 | |
| 54 | Shane McClanahan# | .5926 | 2023 | |
| 54 | Bob Feller | .5926 | 1948 | |
| 56 | Billy O'Dell | .5935 | 1962 | |
| 57 | Johnny Kucks | .5968 | 1957 | |
| 58 | Billy O'Dell | .5985 | 1963 | |
| 59 | Catfish Hunter | .5989 | 1966 | |
| 60 | Justin Verlander# | .5990 | 2020 | |
| 60 | Clayton Kershaw# | .5990 | 2013 | |
| 62 | Aaron Poreda | .5991 | 2010 | |
| 63 | Stephen Strasburg | .5992 | 2013 | |
| 64 | Chris Tillman | .5993 | 2015 | |
| 65 | Sandy Koufax | .5996 | 1960 | |
| 66 | Johnny Antonelli | .6003 | 1955 | |
| 67 | Felix Hernandez | .6006 | 2011 | |
| 68 | Patrick Corbin# | .6021 | 2013 | |
| 69 | Max Scherzer# | .6025 | 2015 | |
| 70 | Bob Feller | .6032 | 1953 | |
| 70 | Eric Berger | .6032 | 2010 | |
| 72 | Max Scherzer# | .6040 | 2022 | |
| 73 | Justin Verlander# | .6041 | 2022 | |
| 74 | Bill Stafford | .6044 | 1962 | |
| 75 | Patrick Corbin# | .6049 | 2019 | |
| 76 | Yu Darvish# | .6050 | 2016 | |
| 77 | CC Sabathia | .6062 | 2009 | |
| 78 | Danny Salazar | .6079 | 2017 | |
| 79 | Matt Harvey | .6085 | 2015 | |
| 80 | Bob Feller | .6090 | 1950 | |
| 81 | Chris Archer | .6091 | 2016 | |
| 82 | Bob Feller | .6099 | 1949 | |
| 82 | Mike Foltynewicz | .6099 | 2019 | |
| 84 | Mat Latos | .6101 | 2015 | |
| 84 | Cole Hamels | .6101 | 2007 | |
| 84 | Stephen Strasburg | .6101 | 2016 | |
| 87 | Freddy Peralta# | .6110 | 2021 | |
| 88 | Catfish Hunter | .6112 | 1968 | |
| 89 | Jake Peavy | .6117 | 2007 | |
| 90 | Shane McClanahan# | .6118 | 2024 | |
| 91 | Billy O'Dell | .6122 | 1960 | |
| 92 | Jacob Degrom# | .6127 | 2022 | |
| 92 | Dylan Cease# | .6127 | 2025 | |
| 94 | Robbie Ray# | .6129 | 2019 | |
| 95 | Stephen Strasburg | .6135 | 2012 | |
| 96 | Felix Hernandez | .6140 | 2006 | |
| 97 | Chris Tillman | .6142 | 2014 | |
| 98 | Catfish Hunter | .6146 | 1969 | |
| 99 | Aaron Harang | .6152 | 2008 | |
| 100 | Lance McCullers Jr.# | .6153 | 2021 |
